Research Programs

SBI is engaged in a broad portfolio of research initiatives to deepen systems-level understanding of biology and apply those insights to challenges in medicine, global energy, and climate resilience.

Themes of Research

AI for Science — Nobel Turing Challenge

Artificial intelligence is reshaping the scientific method. SBI develops AI-guided discovery pipelines that connect biological data, autonomous experimentation, and interpretable analytics to accelerate impact in healthcare, global energy, and climate research.

Computational Platform for Systems Biology (CPSB)

Robust systems biology research relies on interoperable standards, simulation platforms, and analysis toolchains. SBI leads development of:

• Systems Biology Markup Language (SBML)
• Systems Biology Graphical Notation (SBGN)
• CellDesigner™
• Large-scale molecular interaction maps and curation infrastructure
• Text mining pipelines for pathway construction
• Influenza host-response analysis platforms
• PhysioDesigner / FLINT for physiological modelling
• The Garuda Alliance and Garuda Platform

Theoretical Studies on Biological Robustness

Robustness is a defining property across biological scales. SBI explores the coupling between robustness, evolvability, fragility, and performance trade-offs to reinterpret disease mechanisms and therapeutic opportunities. Research spans:

• Theory of biological robustness
• Robustness of cellular systems
• Clinical trade-offs and resilience-informed medicine

Systems Drug & Therapy Design

By viewing cancer and complex diseases as robust, evolvable systems, SBI investigates multi-component treatment strategies that harness inherent trade-offs. Current focus areas include:

• Multi-component therapeutics
• Herbal medicine programmes
• Precision oncology and dormancy control strategies

Additional Focus Areas

• Neurological disease systems models
• Infectious disease platforms
• Toxicology networks
• Whole-yeast modelling (signal transduction and cell cycle)
• Coral reef symbiosis and resilience studies
• Microbiome dynamics in health and environment

For collaboration inquiries please contact [email protected].